Wilburworld of Science

Activity:  Karyotyping -  Students create a simulated human karyotype analyzing human chromosomes to diagnose disease.  

After completing this activity students will
  • know karyptype, homologous chromosomes, centromere, chromatids
  • know monosomy, trisomy, chromosomal alterations
  • be able to match homologues according to morphological characteristics of chromosomes and interpret karyotypes to diagnose genetic disorders.  
Take-Home Quiz/WebQuest:  Chromosomal Disorders
Lab: Preparation of Human Chromosome Spreads - Students learn how to affix, stain and visualize human chromosomes mounted on  microscope slides.  

After completing this lab, students will
  • be able to create a chromosome spread
  • understand the role of colchicine and stains in visualizing chromosomes
Lab: Observation of Human Chromosome Spreads - Students observe chromosome morphology and count chromosomes to assess abnormalities.  

After completing this lab, students will
  • be able to assess chromosome spreads and diagnose genetic disorders
Watch:  HOUSE Episode -

B         

PPT/Notes: Genetic Testing & Karyotypes 

After completing this activity students will
  • understand that genetic testing can include analysis of whole chromosomes, specific gene sequences or protein shape and function
A chromosome Spread is a diagnostic tool for determining chromosomal abnormalities relating to genetic disorders.    
Disease Diagnostics         
Unit 3: Genetic Diseases/Disorder
Chromosomal Mutations
Feb 10, Mon, Day F
Feb 11, Tues, Day A
Feb 12, Wed, Day B
Feb 13, Thur, Day C
Feb 14, Fri, Day D
Feb 7, Fri, Day E