Wilburworld of Science

Activity:  Pedigree Investigator On the Case of Nicotine Addiction - Students interview a family, document patterns and construct and analyze a pedigree to determine if there is a genetic predisposition / component to nicotine addiction.  

After completing this investigative analysis, students will
  • be able to look for patterns within a pedigree that indicate whether or not the trait being tracked is inherited
  • understand that constructing a pedigree is only the first step in identifying genes involved in disease, which would be followed by comparison of entire human genomes
Activity:​ Pick the Risk: The Polygenic Pedigree Challenge - Students are challenged to track and record the passage of colored genes through generations of a family using a pedigree.                   

After completing this activity, students will 
  • understand that common chronic diseases such as heart disease, run in families and are caused by the combined action of multiple genes as well as environmental factors. 

Quiz:  Genetic Diseases/Disorders
Activity/Video Epigenetics - A 3-D cut-and-paste model depicting how histone, acetyl and methyl molecules control access to DNA and affect gene expression. 

​After creating and manipulating this model, students will
  • know the structures and functions of histones, methyl and acetyl groups
  • understand the role of methyl and acetyl molecules as related to the activation and inactivation of genes




Animation / Interactive Explorer  Epigenetics  

After watching this animation, students will
  • understand that the epigenome influences gene expression

Watch:  HOUSE Episode -
​Finding Judas

Acute Pancreatitis        
Gall stones
Abdominal ultrasound
CT scan
Broad Spectrum Antibiotic
Metronidazole
Neuraxonal dystrophy
Wilson's Disease
Reye Syndrome
Blood clot
Thrombocytopenia
Anemic
Varicella (chicken pox)
Rickettsialpox
Rocky Mountain Spotted Fever
Necrotizing fasciitis
Congenital erythropoietic porphyria​

Disease Diagnostics         
Unit 3: Genetic Diseases/Disorder
Multifactorial Disorders
Site/Activity:  The PTC Gene - Students assess which allelic version of a particular taste receptor they have.  Reading & Class discussion about genetic applications to addiction predisposition.  
Mar 12, Wed, Day E
Mar 13, Thur, Day F
Mar 14, Fri, Day A
Mar 17, Mon, Day B
Mar 18, Tues, Day C
Activity/Ethical Debates:  SNP Analysis & Pharmacogenetics - Students learn about Single Nucleotide Polymorphisms in DNA sequences and how thy can be used to match patients with appropriate medications.  Students locate the SNP's in DNA sequences for fourteen patients, categorize them into haplotypes (same SNP's) and prescribe a medication to a fictitious patient based on their DNA sequence.  


After completing this activity, students will
  • know SNP's, haplotypes, pharmacogenetics
  • be able to locates SNP's in genetic sequences and group DNA sequences into haplotypes
  • understand that people with different haplotypes respond differently to different mecations
Video Clip:  Epigenetics, Twins & Diet - A brief
Mar 19, Wed, Day D
Mar 20, Thur, Day E
Animation: Your Doctor's New Genetic Tools - An example of how genetic testing can help doctor's prescribe the correct dose of medication. 
Animation:  Making SNP's Make Sense -